Abstract
Background and Objectives: Colorectal cancer (CRC) is the second-most common cause of cancer-related deaths worldwide. Angiogenesis is crucial for cancer growth, infiltration of surrounding tissues, and metastasis and plays a key role in the pathogenesis of CRC. Chemerin/chemokine-like receptor 1 (CMKLR1) is one of the biochemical pathways involved in the regulation of angiogenesis in solid tumors. The aim of the study was to assess the CMKLR1 level in tumor and margin tissues of CRC in relation to histopathological parameters: microvessel density (MVD), budding, tumor-infiltrating lymphocytes (TILs), TNM scale, and grading. Materials and Methods: The study involved 43 samples of tumor and margin tissues obtained from CRC patients. To assess the concentration of CMKLR1 a commercially available enzyme-linked immunosorbent assay kit was used. For 35 cases, we performed CD34 immunostaining. The MVD, budding, and TILs were assessed using a light microscope. Results: The levels of CMKLR1 in both tumor and margin were negatively correlated with MVD and budding. CMKLR1 concentration in margin was higher in tissues with lymphocytic infiltration. Conclusions: Low vascularity and low budding are associated with higher CMKLR1 expression. CMKLR1 might play a multifunctional role in CRC pathogenesis by influencing tumor budding and peritumoral lymphocytic infiltration.
Highlights
Colorectal cancer (CRC) is the second leading cause of cancer-related death, killing annually more than 900,000 patients worldwide [1]
In addition to the well-studied proangiogenic factors, i.e., vascular endothelial growth factor (VEGF) and vascular cell adhesion molecule, recent studies mention the pathway of chemerin/chemokine-like receptor 1 (CMKLR1), as a factor involved in promoting angiogenesis [5]
The main aim of our study was to determine whether the concentration of CMKLR1 in tissue is associated with microvessel density (MVD) in CRC and to assess its relationships with tumor histopathological parameters: budding and tumor-infiltrating lymphocytes assessment (TILs) [11]
Summary
Colorectal cancer (CRC) is the second leading cause of cancer-related death, killing annually more than 900,000 patients worldwide [1]. Angiogenesis is crucial for cancer growth, infiltration of surrounding tissues, and metastasis and plays a key role in the pathogenesis of CRC. Chemerin/chemokine-like receptor 1 (CMKLR1) is one of the biochemical pathways involved in the regulation of angiogenesis in solid tumors. The aim of the study was to assess the CMKLR1 level in tumor and margin tissues of CRC in relation to histopathological parameters: microvessel density (MVD), budding, tumorinfiltrating lymphocytes (TILs), TNM scale, and grading. Materials and Methods: The study involved 43 samples of tumor and margin tissues obtained from CRC patients. CMKLR1 concentration in margin was higher in tissues with lymphocytic infiltration. CMKLR1 might play a multifunctional role in CRC pathogenesis by influencing tumor budding and peritumoral lymphocytic infiltration
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