Abstract
The concentration of ceruloplasmin in blood of tumor-bearing rats after administration of a dirhenium(III) compound and cisplatin
Highlights
Introduction ofcPt solutions to tumor-bearing rats showed different directions of changing of Cp levels in T8 and T8* groups of animals: if introduction of cPt to T8 group led to increasing of Cp level on 22.9% in comparison to T8 group, the same introduction to T8* group led to decreasing of Cp on 27.0% in comparison to T8* group of animals
We studied the cluster compound dichlorotetra-μ-isobutyratodirhenium(ІІІ)
Development of a cPt-resistant tumor T8* led to increasing of Cp concentration in 2.3 times more intensively in comparison to ordinary tumor T8. These findings may support the upper citedworks about essential role of Cp in the formation of resistance phenomenon in cancer cells [7,8,9]
Summary
CPt solutions to tumor-bearing rats showed different directions of changing of Cp levels in T8 and T8* groups of animals: if introduction of cPt to T8 group led to increasing of Cp level on 22.9% in comparison to T8 group, the same introduction to T8* group led to decreasing of Cp on 27.0% in comparison to T8* group of animals. To our knowledge, such an essential difference in elevation or dropping of Cp levels as a reply to cisplatin solution introductions is first demonstrated.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
