Abstract
In demyelinating diseases in humans, multiple sclerosis and subacute sclerosing panencephalitis, the concentration of γ-globulin in cerebrospinal fluid (CSF) is increased. In an attempt to elucidate the mechanism behind this increase we sought an animal model for the diseases. We measured the concentration of albumin and γ-globulin in CSF and plasma from nine rabbits with experimental allergic encephalomyelitis. Both in CSF and plasma the concentration of γ-globulin was significantly increased, but no significant changes in the albumin concentration was observed. Thus experimental allergic encephalomyelitis resembles multiple sclerosis and subacute sclerosing panencephalitis with regard to the changes in protein concentration in CSF and plasma.
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