Abstract
Detoxified saponin (Solryth ™ ) has been found to be a stable, rapid and effective mucolytic agent which does not inhibit the growth of bacteria or fungi. In comparing quantitative sputum lysis using Solryth ™ with a conventional semiquantitative method, the former technique was found to yield more reproducible and less ambiguous results. For most potentially pathogenic organisms, a bacterial concentration of >10 7 colony-forming units (CFU) per milliliter of digested sputum is highly suggestive of infection in most cases. The data also suggest that the diagnostic threshold for lung infection caused by saprophytic species of Hemophilus appears to be >108/ml. The quantitative method has a 1.5% falsepositive rate (2/128 patients were positive for organisms which were not clinically significant) as compared to 48% (61/128) of the conventional cultures. The conventional and quantitative methods failed to recover a significant organism in nine and four cases, respectively. Regardless of the technique used, prior throat cultures, proper specimen collection, sputum grading and repeat specimens are necessary to obtain meaningful results.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
