Abstract
Abstract The tabletting characteristics of crystalline and spray dried lactose under direct compression have been examined together with the effect of particle size, shape and storage of the powders. The results indicated that the particle size had little effect, although there was a general tendency for the compact strength to increase as the particle size decreased. On the other hand, the particle shape and storage of the powder influenced the strength of the tablets and the force lost to the die wall. The 22 μm and 35 μm fractions of spray dried lactose—especially the latter—were almost entirely very regular spherical particles which resulted in the strongest tablets, whereas fractions below or above contained many more angular particles resulting in weaker tablets. Storage of the small particle size fraction of the crystalline material appeared to induce aggregation, and on compaction, a harder tablet was formed, accompanied by a decrease in the force lost to the die wall.
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