Abstract
• .Aptamer - phthalocyanine - quantum dots are used as sensors for prostate antigen. • Electrochemical impedance spectroscopy is employed to determine detection limits. • Low detection limit of 0.27 ng/mL in real sample. Asymmetrical phthalocaynine molecules have been employed in combination with graphitic carbon nitride quantum dots covalently linked to an amine-functionalized aptamer for the electrochemical detection of prostate cancer biomarker. The combination of the phthalocyanine complexes with the quantum dots-aptamer conjugate resulted in an overall improved electrocatalytic ability as well as enhanced signal response. Moreover, results proved one of the complexes being superior over the other functionality wise, indicating the significance of substituent type of the phthalocyanines. The best performing aptasensor showed detection limits as low as 0.23 ng/mL in buffer solutions as well as 0.27 ng/mL in serum samples. Moreover, the sensor showed good stability, reproducibility and repeatability.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
