Abstract
Skin lesions of 15 bullous pemphigoid patients were examined for the presence of Clq, C3, C3 proactivator (C3PA), and properdin in addition to immunoglobulins (IgG, IgA, and IgM) and fibrin using immunofluorescent (IF) techniques. Properdin and C3 were present along the skin basement-membrane zone in all of the lesions studied in addition to immunoglobulins. Deposition of C3PA was found in only 5 of 15 skin speciments with considerably less staining intensity than that observed for C3 and properdin. Deposition of Clq was present in 12 of 15 skin lesions while fibrin deposition was present in 11 of 15 skin lesions. Absorption of anti-C3PA and antiproperdin with C3PA and properdin, respectively, blocked the specific staining reactions. These studies, therefore, suggest local activation of complement, by both the classical and alternate pathways, in bullous pemphigoid skin lesions.
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