Abstract
BackgroundThis study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function.MethodsA total of 77 subjects (64.5 ± 10.8 years, 67.5% females) without documented cardiovascular disease were prospectively recruited. All subjects underwent transthoracic echocardiography, baPWV and noninvasive measurement of CBP on the same day.ResultsIn simple linear correlation analyses, neither baPWV nor CBP was associated with LV mass index or relative wall thickness (P > 0.05 for each). Although baPWV significantly correlated with septal e´ velocity in simple linear correlation analyses (r = 0.258, P = 0.025), the significance was lost after controlling for potential confounder (P = 0.881). In simple linear correlation analyses, central systolic blood pressure (CSBP) and central pulse pressure (CPP) significantly correlated with both septal e´ velocity or E/e´ (P < 0.05 for each); however, neither central diastolic nor mean arterial pressures was associated with both septal e´ velocity and E/e´ (P > 0.05 for each). After controlling for confounders, including age, sex and body mass index, CSBP correlated with septal e´ velocity (β = − 0.258, P = 0.025), but not with E/e´ (P = 0.074). CPP correlated with both septal e´ velocity (β = − 0.300, P = 0.014) and E/e´ (β = 0.428, P = 0.002) in the same multivariable model.ConclusionsIn subjects without documented cardiovascular disease, CSBP and CPP may be more strongly associated with LV diastolic function than baPWV. Further studies with a larger sample size are needed to confirm our results.
Highlights
This study was performed to compare the associations of brachial-ankle pulse wave velocity and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function
This study was performed to compare the associations of brachial-ankle pulse wave velocity and CBP measurements with LV geometry and diastolic function
The mean value of White blood cell (WBC) count, hemoglobin concentration, serum level of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglyceride, HbA1c, glomerular filtration rate, and C-reactive protein were within the normal range
Summary
This study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function. Decreased central diastolic blood pressure (CDBP) in a stiffened aorta reduces coronary perfusion [15]. Both arterial stiffness and CBP have a significant impact on the LV, most of the prior studies have only focused on arterial stiffness or CBP. This study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and CBP measurements with LV geometry and diastolic function
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