Abstract
Background: Helicobacter pylori is the most common cause of chronic gastritis in the world, meanwhile gastritis caused by non-steroidal anti-inflammatory drugs (NSAIDs) is the most encountered type of gastritis.Increased free radicals caused by Helicobacter pylori can cause damage in gastric mucous. Tissue damage due to free radicals can be examined by measuring malondialdehyde compound. There are many studies thatproves the increased malondialdehyde in gastritis, but those studies commonly done in animal experimentation and malondialdehyde examination in gastric mucous.Method: This is a cross-sectional study of 40 dyspepsia patients who came to endoscopic unit of Adam Malik General Hospital Medan and networking hospitals by using Rome III criteria. Further examination with gastroscopy and biopsy was done to determine gastritis. H. pylori examination was done by using Campylobacterlike organism test (CLO) test. Serum malondiasldehyde level was examined with high performance liquid chromatography (HPLC) method.Results: From total of 40 patients,24 (60%) were men and 16 (40%) were women with an average age of 47years, the majority of the ethnic was Bataknese (57.5%). From 20 patients with H.pylori (+), the average levelof malondialdehyde was 1.58 umol/mL while in 20 other patients with H. pylori (-), malondialdehyde level was 1.19 umol/mL with p value 0.013.We found the mean serum levels of malondialdehyde was higher in H. pyloripositive gastritis than H. pylori negative.Conclusion: Serum Malondialdehyde level was significantly higher in patient with positive H. pylori gastritiscompared to H. pylori negative gastritis.
Highlights
Gastritis is an inflammation process in gastric mucous and submucous as a response to acute or chronic injury
From 20 patients with H.pylori (+), the average level of malondialdehyde was 1.58 umol/mL while in 20 other patients with H. pylori (-), malondialdehyde level was 1.19 umol/mL with p value 0.013.We found the mean serum levels of malondialdehyde was higher in H. pylori positive gastritis than H. pylori negative
Serum Malondialdehyde level was significantly higher in patient with positive H. pylori gastritis compared to H. pylori negative gastritis
Summary
Gastritis is an inflammation process in gastric mucous and submucous as a response to acute or chronic injury. Helicobacter pylori infection is the most common cause of active chronic gastritis in the world, chemical gastritis due to NSAID is the second most common risk factor in gastritis.[1]. H. pylori infection will cause neutrofil and macrofage/monosit recruitment which in turn increase free radical that implied in gastric mucous damage. Lipid tissue damage due to free radical that can be measured with malodialdehyde compound measurement which is a lipid peroxidase product. Helicobacter pylori is the most common cause of chronic gastritis in the world, gastritis caused by non-steroidal anti-inflammatory drugs (NSAIDs) is the most encountered type of gastritis. Increased free radicals caused by Helicobacter pylori can cause damage in gastric mucous. Tissue damage due to free radicals can be examined by measuring malondialdehyde compound. There are many studies that proves the increased malondialdehyde in gastritis, but those studies commonly done in animal experimentation and malondialdehyde examination in gastric mucous
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