The comparison of pancreatic and hepatic steatosis in healthy liver donor candidates

Bedriye Koyuncu Sokmen,Alihan Oral,Tolga Sahin,Erdem Kocak,Nagihan Inan

doi:10.1038/s41598-021-83871-0

Bedriye Koyuncu Sokmen, Alihan Oral + Show 3 more

Open Access

https://doi.org/10.1038/s41598-021-83871-0

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Journal: Scientific Reports	Publication Date: Feb 24, 2021
Citations: 6	License type: open-access

Affiliation: Istanbul Bilim University

Abstract

The aim of this study was to investigate the relationship between nonalcoholic fatty liver disease (NAFLD) and pancreatic steatosis (PS) in patients with biopsy-proven NAFLD. 228 patients with biopsy-proven NAFLD patients who admitted to the Faculty of Medicine of Demiroglu Bilim University between 2004 and 2019 were included in the study. Demographic, laboratory, histological and radiological findings of the patients were recorded retrospectively. Hepatosteatosis (HS) levels were measured by both CT and biopsy, while PS levels were measured by 3 different CT-based techniques. 89 (39%) of the patients were female and 139 (61%) were male. The mean body mass index (BMI) was 27.2 ± 4.0. Biochemical parameters were within normal limits. Liver biopsy showed a significant correlation with HS grade on CT scan (p < 0.001). When CT findings were compared, a significant correlation was found between PS and HS (p < 0.05), but there was no correlation between the HS level in biopsy and the pancreatic adiposity on CT (p > 0.05). Our study was the first to compare biopsy-proven NAFLD and PS, and no correlation was found between biopsy-proven NAFLD and PS.

Highlights

In the study by Bi et al, a total of 13 studies involving 49 329 subjects were included
Many radiological methods have been reported for the evaluation of PS in the literature, such as ultrasound (US), endoscopic ultrasound (EUS), computed tomography (CT) and magnetic resonance imaging (MRI)
Pancreatic and hepatic steatosis rates measured by CT were correlated as in many other studies, no significant correlation was found between liver biopsy findings and PS

Summary

Introduction

In the study by Bi et al, a total of 13 studies involving 49 329 subjects were included. This analyses elucidated the presence of non alcoholic fatty pancreas disease (NAFPD) and was associated with a significant increased risk of metabolic syndrome, hypertension, nonalcoholic fatty liver disease (NAFLD), diabetes mellitus and central obesity. CT is one of the most commonly used radiologic methods for the evaluation of PS and NAFLD14. Despite the power of CT and many other radiological methods in the diagnosis of HS, liver biopsy is still considered the gold standard method in diagnosing NAFLD17. Many studies have associated NAFLD and NAFPD using different methods, there are no studies comparing NAFPD with biopsy-proven NAFLD.

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