Abstract
Background: patients with type 2 diabetes (T2DM) are subjected to reduction in the quality and oxidative capacity of muscles. The effect of duration of diabetes on the muscle endurance response is not clear and strength as well .The aim of this study was the assessment of strength and endurance of knee extensor and flexor in the patients with T2DM<10 and T2DM>10 years in comparison with age, sex, BMI, ABI and PAI-matched health control subjects. Methods: isometric maximal peak torque (MPT) of knee extensor and flexor before and after 40 isokinetic repetitions with velocity of 150 degree/s were recorded in 18 patients with T2DM<10 Y , 12 patients with T2DM>10 Y and 20 matched health control (HC) groups. Results: both diabetic patient groups had significant lower isometric and isotonic knee extensor and flexor strength than HC (Table 1). The endurance indices indicated that whereas the isometric MPT of flexor movement was reduced after isokinetic protocol in the both patient groups in comparison with HC, the less decline was seen in the isotonic torque and work during isokinetic protocol in the T2DM>10 Y group in comparison with two other groups (figure 1). The HbA1c and FBS were significantly correlated with strength not with endurance indices. Conclusions: it seems the progression of diabetes accompanied with vascular, neural and muscular deficits activate, some adaptive and compensatory processes which can maintain muscle performance.
Highlights
Patients with type 2 diabetes (T2DM) are subjected to reduction in the quality and oxidative capacity of muscles
It seems the progression of diabetes accompanied with vascular, neural and muscular deficits activate, some adaptive and compensatory processes which can maintain muscle performance
Thirty patients participated in the study and they categorized into two groups according to the duration of diagnosed diabetes, 18 patients with less than 10 years of disease in the Type 2 diabetes mellitus (T2DM) < 10 Y group and 12 patients with equal and more than 10 years of disease were placed in theT2DM > 10 Y group
Summary
Patients with type 2 diabetes (T2DM) are subjected to reduction in the quality and oxidative capacity of muscles. The effect of duration of diabetes on the muscle endurance response is not clear and strength as well. The results showed that healthy participants were fatigued more than long-term T2DM during 30 maximal isokinetic movements of knee and ankle at 180 degree/s was not number of capillaries around muscle fiber [13], number of mitochondria and oxidative capacity [16], GLUT4 and the insensitivity to insulin [17]. There is no evidence to investigate the effect of diabetes with different duration on the endurance property of diabetic muscles. The assessment of strength and endurance in the static and dynamic conditions in the short intensive exercise in the patients with the less and more than 10 years of diabetes in the comparison with sex, age, BMI, PAI (physical activity index) and ABI (ankle brachial index) matched healthy subjects may clarify the relation of strength and endurance changes with the duration of diabetes
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
