Abstract
Background To compare the multimodal imaging findings of chronic central serous chorioretinopathy (CSC) patients who are good or poor responders to low-fluence photodynamic therapy (PDT).MethodsRetrospective, interventional comparative study. The CSC patients who were admitted to our clinic for the first time between January 2013 and December 2015 were included in the study. Patients were treated with PDT only if they did not show any sign of resolution after at least 6 months from the initial signs of the disease. The patients who showed full or partial response to PDT after 3 months of treatment were accepted as good responders, those who did not show any sign of resolution were accepted as poor responders. The optical coherence tomography (OCT), fluorescein angiography (FA), and indocyanine green angiography (ICGA) findings were compared between the two groups.ResultsA total of 101 eyes of 101 patients were included: 76 eyes (75.2%) were considered as good responders and 25 eyes (24.8%) as poor responders. In regards to OCT and FA findings there was not a significant difference between the two groups for all of the evaluated findings (p > 0.05 for all). In regards to ICGA findings, there was a statistically difference in the percentage of intense midphase hypercyanescence (p < 0.0001).ConclusionsThe multimodal imaging findings of CSC patients were compared in regard to their PDT response. The presence of midphase hypercyanescence in ICGA seemed to be positive predictive factor for the PDT response in CSC patients.
Highlights
To compare the multimodal imaging findings of chronic central serous chorioretinopathy (CSC) patients who are good or poor responders to low-fluence photodynamic therapy (PDT)
Photodynamic therapy was first introduced for the treatment of neovascular age-related macular degeneration where it was no longer used after the introduction of the anti-vascular endothelial growth factor agents [8]
In this study we evaluated the associations between the optical coherence tomography (OCT), fluorescein angiography (FA), and indocyanine green angiography (ICGA) findings and the anatomically PDT response in chronic CSC patients
Summary
To compare the multimodal imaging findings of chronic central serous chorioretinopathy (CSC) patients who are good or poor responders to low-fluence photodynamic therapy (PDT). Ozkaya et al Int J Retin Vitr (2017) 3:20 patients, choroidal vascular anomalies and leakage was shown via ICGA, and subfoveal choroidal thickness was found to be thicker via EDI-OCT, two essential findings supporting further the role of choroidal dysfunction in the pathogenesis [3,4,5]. Photodynamic therapy (PDT) has been found to be an effective treatment option in polypoidal choroidal vasculopathy (PCV) and CSC which have been classified under the pachychoroid spectrum disorders [9]. In this study we evaluated the associations between the optical coherence tomography (OCT), fluorescein angiography (FA), and ICGA findings and the anatomically PDT response in chronic CSC patients
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