Abstract
BackgroundPatients with ≥ 3 recurrent spontaneous miscarriages are classified as having RSM. Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR). The purpose of this study is to evaluate the association of IR and RMS.MethodsPresent case- control prospective study was performed on 100 women in control group (with a history of at a live birth and no history of one more abortion) and study group (with a history of ≥ 3 RMS) who were not diabetes and PCOS. Two groups matched in base of age and body mass index. Blood was withdrawn from the case and control patients for the determination of the fasting blood glucose (FG), fasting insulin (FI) levels and ultrasonography was performed on all the patients.ResultsThe observed differences between age, FG and FG to FI ratio levels in case and control groups were not significant (p > 0.05) but it was significant about fasting insulin (p = 0.0119). FI of < 20 μu/ml or ≥ 20 μu/ml in case and control group was significant (Chi-square: 4.083, p: 0.0433, odds ratio: 4.4386, CI95% = 1.1541 to 17.0701), whereas the difference between absolute and proportional frequency of patients with FG to FI ratio of < 4.5 and ≥ 4.5 in case and control groups was not significant (Chi-square: 2.374, p = 0.123).ConclusionCurrent study showed that in women with RPL, in Iranian race like Americans, frequency of insulin resistance in high, therefore there is a probability of the degree of insulin resistance in women with RPL.
Highlights
Patients with ≥ 3 recurrent spontaneous miscarriages are classified as having RSM
Blood was withdrawn from the case and control patients for the determination of the fasting blood glucose (FG) and fasting insulin (FI) levels
Based from the results taken from independent Sample t-test about comparison of the mean of age, fasting blood glucose (FG), fasting insulin (FI) and FG to FI ratio levels in case and control is shown in- Table 1, the observed differences between age, FG and FG to FI ratio levels in case and control groups were not significant (p > 0.05) but it was significant about fasting insulin (p = 0.0119)
Summary
Patients with ≥ 3 recurrent spontaneous miscarriages are classified as having RSM. Polycystic ovary syndrome (PCOS) is associated with insulin resistance (IR). The purpose of this study is to evaluate the association of IR and RMS. Patients with ≥ 3 recurrent spontaneous miscarriages are classified as having RSM. An RSM remains is a very disturbing event to the affected patients by this health problem; they are always anxious to find the underlying reasons for their miscarriages. This is a major challenge to the treating physicians [2]. It is a major hazard in pregnancy, both for naturally conceived and those after assisted reproductive technology (ART) treatment [3].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
