Abstract
Background: This study is designed to compare the degree of attenuation of hemodynamic response to induction, laryngoscopy and endotracheal intubation of etomidate with those of propofol in patients undergoing noncardiac surgical procedures.
 Methods: The present study conducted in Non Cardiac Surgeries in the Department of Anaesthesiology, Jhalawar Medical College & Associated Hospitals, Jhalawar, Rajasthan.After institutional ethical committee’s approval and written informed consent from the patient’s attendant in the format as per proforma, the present study was conducted on 60 patients of ASA Grade I and II of either sex, aged 18 to 60 years, scheduled for a variety of non-cardiac surgical procedures requiring general anaesthesia.
 Results: The findings of the study suggest that use of etomidate as inducing agent provides more hemodynamic stability as compared to propofol and can be preffered in patients prone to hemodynamic instability, cardiovascular abnormalities, hypovolemia, prone to renal failure due to hypotension. Propofol may be preffered for induction where hypertension is contraindicated or hypotension is preffered and myoclonus is to be avoided.
 Conclusion: Etomidate provides a more stable hemodynamics during general anesthesia as compared to propofol.
 Keyword:- Etomidate, Propofol, Hemodynamic.
Highlights
The present study conducted in Non Cardiac Surgeries in the Department of Anaesthesiology, Jhalawar Medical College & Associated Hospitals, Jhalawar, Rajasthan.After institutional ethical committee’s approval and written informed consent from the patient’s attendant in the format as per proforma, the present study was conducted on 60 patients of ASA Grade I and II of either sex, aged 18 to 60 years, scheduled for a variety of non-cardiac surgical procedures requiring general anaesthesia
General anaesthesia (GA) or narcosis is a state of pharmacologically induced coma, temporary and reversible, which is characterized by the development of unconsciousness, analgesia, amnesia, myorelaxation and attenuation of autonomic response to painful stimulation
Various inhalational and intravenous agents are used for induction of GA which consists of the following stages: Stage 1 of analgesia, Stage 2 of delirium/excitement, Stage 3 of surgical anaesthesia and Stage 4 of medullary paralysis
Summary
General anaesthesia (GA) or narcosis is a state of pharmacologically induced coma, temporary and reversible, which is characterized by the development of unconsciousness, analgesia, amnesia, myorelaxation and attenuation of autonomic response to painful stimulation. Propofol is an ultra-short-acting intravenous induction agent with some favourable properties like smooth induction, quick recovery and antiemetic properties It is deemed not a suitable agent in patients with cardiovascular instability and shock as it decreases blood pressure, cardiac output and systemic vascular resistance due to inhibition of sympathetic vasoconstriction and impairment of baroreceptor reflex regulatory system. This effect may be exaggerated in hypovolemic and elderly patients with compromised left ventricular function due to coronary artery disease. This study is designed to compare the degree of attenuation of hemodynamic response to induction, laryngoscopy and endotracheal intubation of etomidate with those of propofol in patients undergoing noncardiac surgical procedures.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
