Abstract
Introduction Melasma is a common acquired illness with outbreak of brown and often symmetrical hypersegmented patches on frequently sun-exposed areas of the face (1 and 2). Melasma accounts for about 4 to 10 percent of the complaints of those visiting skin clinics and is more common among Hispani
Highlights
Melasma is a common acquired illness with outbreak of brown and often symmetrical hypersegmented patches on frequently sunexposed areas of the face[1,2]
Group A was treated with 5-mg finasteride (Suha Pharmaceutical Co., Iran) with 4% topical hydroquinone and group B was treated with placebo and 4% topical hydroquinone
The results showed that the difference between the first and second melasma area and severity index (MASI) in the two study groups was the highest and this difference in the finasteride and placebo groups were respectively 2.9 and 1.19 (Table 2)
Summary
Melasma is a common acquired illness with outbreak of brown and often symmetrical hypersegmented patches on frequently sunexposed areas of the face[1,2]. The pathogenesis of melasma is not completely known. Factors such as RASSAI & MEHRJUI, Biomed. Pregnancy, use of oral combination contraceptives (OCP), stress, exposure to ultraviolet radiation, endocrine factors, genetic and racial factors, and autoimmune disorders like thyroid disease are known as effective on its outbreak or development[1, 4,5,6]. Accurate protection against sun like using sun hats and sunscreens are essential in melasma treatment, other treatments are necessary.Topical treatments include skin whitening agents (hydroquinone, kojic acid), tretinoin, azelaic acid, and chemical peels (retinol-trichloroacetic). Melasma treatment is often not satisfactory and treatment with topical medications is followed by numerous side effects such as contact dermatitis, inflammation, and ulcers3, . 9,10
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