Abstract
Introduction: Diabetes mellitus (DM) is now seen as a worldwide epidemic disease with high prevalence. Exercise training (ET) is known to promote beneficial changes in diabetic patients. The aim of this study was to compare the impact of continuous and intermittent aerobic training on glucose-4 transporter protein (GLUT-4) levels and insulin sensitivity in diabetic rats. Materials and methods: This research was an experimental and interventional study. A number of 60 male rats weighing 180 to 310 grams and 13 weeks old were divided into six groups: healthy control, healthy continuous, healthy intermittent, diabetic control, diabetic continuous, and diabetic intermittent groups. The exercise protocol in both continuous and intermittent groups was aerobic training for six weeks which was conducted considering overload principle. The data were analyzed using one-way analysis of variance test in P< 0.05 level. Results: The results showed that despite the significant difference between insulin resistance and GLUT4 level among diabetic rats in different groups compared to control group, there was no significant difference between the impact of continuous and intermittent training on these indices (P=1.00). Conclusion: Through increasing the GLUT4 protein content, the continuous and intermittent training improved insulin resistance.
Highlights
Diabetes mellitus (DM) is seen as a worldwide epidemic disease with high prevalence
This means that continuous and intermittent training reduce insulin resistance level in diabetic mice compared to diabetic control group (Figure 1).the continuous (P=1.00) and intermittent (P=0.96) training had not significant effect on insulin resistance level of healthy mice compared to healthy control group; there was no significant difference between the impact of both continuous and intermittent training on insulin resistance (P=1.00)
Comparing the pairs in Tukey test showed that GLUT4 of soleus muscle in diabetic control mice is significantly lower than healthy control group (P=0.006)
Summary
Diabetes mellitus (DM) is seen as a worldwide epidemic disease with high prevalence. The aim of this study was to compare the impact of continuous and intermittent aerobic training on glucose-4 transporter protein (GLUT-4) levels and insulin sensitivity in diabetic rats. Results: The results showed that despite the significant difference between insulin resistance and GLUT4 level among diabetic rats in different groups compared to control group, there was no significant difference between the impact of continuous and intermittent training on these indices (P=1.00). Conclusion: Through increasing the GLUT4 protein content, the continuous and intermittent training improved insulin resistance. The mellitus diabetes is a metabolic disorder that is widespread in the world and is associated with increase in blood glucose, inadequate secretion, and dysfunction of insulin [1]. There is a direct relationship between chronic complications of diabetes and high level of blood glucose [7]. There is no doubt that improved glycemic control in diabetic patient results
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