The comparison of cognitive potential P300 in major depressive disorder between with and without family history

Abstract

Objective To explore the character of cognitive potential P300 in major depressive disorder (MDD)patients between with and without family history and compare the cognitive function between them. Methods Sixty-seven MDD patients with family history and sixty-seven MDD patients without family history were assigned to research group, sixty-seven healthy volunteers were assigned to control group, and ERP P300 detections were conducted in all subjects. Results ①To compare with control group ((189.33±51.13)ms) and MDD without family history group((193.55±40.01)ms), the N2 latency was prolonged more significantly in MDD with family history group((208.40±33.05)ms)(P<0.05). ②Compared with control group((3.38±5.52)μV), the N2 amplitude was decreased more significantly in MDD without((2.47±1.87)μV) and with family history((2.36±2.10)μV), (P<0.05). Conclusion There is an obvious cognitive function damaged in the MDD patients with and without family history and the MDD patients with family history are more serious. Key words: Depression; Recurrent; Cognitive potential; P300