Abstract
Objective To explore the character of cognitive potential P300 in major depressive disorder (MDD)patients between with and without family history and compare the cognitive function between them. Methods Sixty-seven MDD patients with family history and sixty-seven MDD patients without family history were assigned to research group, sixty-seven healthy volunteers were assigned to control group, and ERP P300 detections were conducted in all subjects. Results ①To compare with control group ((189.33±51.13)ms) and MDD without family history group((193.55±40.01)ms), the N2 latency was prolonged more significantly in MDD with family history group((208.40±33.05)ms)(P<0.05). ②Compared with control group((3.38±5.52)μV), the N2 amplitude was decreased more significantly in MDD without((2.47±1.87)μV) and with family history((2.36±2.10)μV), (P<0.05). Conclusion There is an obvious cognitive function damaged in the MDD patients with and without family history and the MDD patients with family history are more serious. Key words: Depression; Recurrent; Cognitive potential; P300
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