The Comparison of Clinical, Histopathological and some Hemodynamic Effects of Spinal Anesthesia Applied in Dogs Through Bupivacaine HCl and Ropivacaine HCl in Two Different Concentrations

Abstract

Summary The aim of this study was to evaluate the side effects of local and systemic clinical, histopathological and hemodynamics by use of isobaric and hyperbaric bupivacaine in different concentrations during spinal anesthesia which has been a common use within the past few years. The study material consisted of 23 healthy stray dogs with dissimilar sex, age and body weight as well as bupivacaine hydrochloride containing Marcaine® %0.5 (Astra Zenaca, Turkey) and Marcaine® Spinal Heavy %0.5 (Astra Zenaca, Turkey), and ropivacaine hydrochloride containing Naropin® 7.5mg/ml (Astra Zenaca, Germany) so as to create the state of spinal anesthesia. A total of 5 different groups were formed where each study group consisted of 5 dogs and the control group consisted of 3 dogs. The groups were as follows: Aa (Marcaine), Ab (Marcaine® Spinal Heavy), Ba (Naropin®), Bb (Naropin® + Dekstroz) and C (Dekstroz). During the anesthesia; blood pressure, pulse and respiratory rates were measured in all groups. Besides, needle punctures were applied from time to time. The animals were euthanized following a one-week long hospitalization. Then, the parts of the spinal cords on which injections were applied were taken off and investigated histopathologically. In this study no significant were observed with regard to the use of ropivacaine HCl and bupivacaine HCl and their clinical, hemodynamic and histopathologic side effects; on the other hand, bupivacaine HCl was found to be considerably superior to ropivacaine HCl regarding the anesthesia duration and depth.