The comparison of autoclaved autogenous bone and fibrin glue as BMP carriers for bone generation in a critical-size segmental defect in the Rat fibula

Abstract

Bone morphogenic proteins (BMPs) have been shown to play an important role in bone formation during development and wound healing. Despite the good prospects for BMP applications, an ideal carrier system for BMPs has yet to be determined. The purpose of this study was to evaluate the possibility of an autoclaved autogenous bone(AAB) as a carrier for recombinant human BMP-2(rhBMP-2) and compare it to well known BMP carriers, AAB and fibrin glue (FG), in a rat fibula defect model.