Abstract
The comparison of the effect of porphyrins of natural and synthetic origin containing the same metal atom on the structure and properties of the semi-crystalline polymer matrix is of current concern. A large number of modifying additives and biodegradable polymers for biomedical purposes, composed of poly(-3-hydroxybutyrate)-porphyrin, are of particular interest because of the combination of their unique properties. The objective of this work are electrospun fibrous material based on poly(-3-hydroxybutyrate) (PHB), hemin (Hmi), and tetraphenylporphyrin with iron (Fe(TPP)Cl). The structure of these new materials was investigated by methods such as optical and scanning electron microscopy, X-ray diffraction analysis, Electron paramagnetic resonance method, and Differential scanning calorimetry. The properties of the electrospun materials were analyzed by mechanical and biological tests, and the wetting contact angle was measured. In this work, it was found that even small concentrations of porphyrin can increase the antimicrobial properties by 12 times, improve the physical and mechanical properties by at least 3.5 times, and vary hydrophobicity by at least 5%. At the same time, additives similar in the structure had an oppositely directed effect on the supramolecular structure, the composition of the crystalline, and the amorphous phases. The article considers assumptions about the nature of such differences due to the influence of Hmi and Fe(TPP)Cl) on the macromolecular and fibrous structure of PHB.
Highlights
One of the most effective ways to create binary compositions based on biocompatible polymers for biomedical purposes is electrospinning (ES) [1]
Of particular interest is the selection of such additives, which can significantly increase the characteristics of known biocompatible polymers, even at low concentrations
Close attention is paid to porphyrins, which a widely used in tumor and gene therapy [5–7], biomedicine [8,9], chemotherapy [10], and drug delivery [11]
Summary
One of the most effective ways to create binary compositions based on biocompatible polymers for biomedical purposes is electrospinning (ES) [1]. ES is a unique technique used for the effective introduction of various modifying additives of natural and synthetic origin [3]. The use of a large number of different additives makes it possible to solve many problems associated with obtaining materials with controlled properties and structure [4]. Of particular interest is the selection of such additives, which can significantly increase the characteristics of known biocompatible polymers, even at low concentrations. Close attention is paid to porphyrins, which a widely used in tumor and gene therapy [5–7], biomedicine [8,9], chemotherapy [10], and drug delivery [11]. Due to their chemical structure, porphyrins possess excellent chemical and thermal stabilities, photophysical and electrochemical performances, and biological compatibility [12]. In terms of the chemical origin and structural differences, two classes of porphyrins—natural and synthetic—can be distinguished [14]
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