Abstract
Regional anesthesia for surgery is associated with increased anxiety for patients. This study aimed to compare the effect of propofol and dexmedetomidine infusion on perioperative anxiety during regional anesthesia. Eighty-four patients were randomly divided into two groups receiving either study drug infusion. Anxiety score, level of sedation using the Bispectral Index and Observer’s Assessment of Alertness and Sedation, hemodynamic stability, and overall patient’s feedback on anxiolysis were assessed. Both groups showed a significant drop in mean anxiety score at 10 and 30 min after starting surgery. Difference in median anxiety scores showed a significant reduction in anxiety score at the end of the surgery in the dexmedetomidine group compared to the propofol group. Dexmedetomidine and propofol showed a significant drop in mean arterial pressure in the first 30 min and first 10 min respectively. Both drugs demonstrated a significant drop in heart rate in the first 20 min from baseline after starting the drug infusion. Patients in the dexmedetomidine group (76.20%) expressed statistically excellent feedback on anxiolysis compared to patients in the propofol group (45.20%). Dexmedetomidine infusion was found to significantly reduce anxiety levels at the end of surgery compared to propofol during regional anesthesia.
Highlights
Regional anesthesia for surgery provides many benefits to patients such as postoperative analgesia, early mobilization in the postoperative period, and minimizing pulmonary complications [1]
Difference in median anxiety scores showed a significant reduction in anxiety score at the end of the surgery in the dexmedetomidine group compared to the propofol group
Dexmedetomidine and propofol showed a significant drop in mean arterial pressure in the first 30 min and first 10 min respectively
Summary
Regional anesthesia for surgery provides many benefits to patients such as postoperative analgesia, early mobilization in the postoperative period, and minimizing pulmonary complications [1]. It is associated with increased stress and anxiety with as many as 23% of patients reported to be anxious on arrival at the operating theater [2]. Anxiety can worsen patients’ perception of pain and increase requirements for postoperative analgesia. Various agents such as propofol and dexmedetomidine are used to relieve anxiety and provide sedation during regional anesthesia [4,5]
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