Abstract
Comparative evaluation of the effectiveness of treatment of patients with osteoarthritis of the knee joint (OA COP) with chondroitine sulfate (CS) and intra-articular injection of hyaluronic acid (HA), as well as their impact on the demand in NSAID therapy and life quality of patients.45 patients (males and females) with OA of the COP in age from 35 to 82 years with duration of disease 7 years were included into the 12-month study. We used SF-36, VAS, radiography and MRI. Patients were devided into 3 groups: Group 1 – intra-articular injections of glucocorticoids 1,0 ml 3-5 a week, Group 2 – 500 mg CS, 1 capsule 2 times a day for 6 months. Group 3 – taking only NSAIDs.There was a significant symptomatic effect of corticosteroids and CS. Therapy with corticosteroids and CS showed slower progression of OA of the COP, that allows to refer them to structural-modifying drugs.
Highlights
to 82 years with duration of disease 7 years were included into the 12-month study
Patients were devided into 3 groups
that allows to refer them to structural-modifying drugs
Summary
СРАВНИТЕЛЬНАЯ ОЦЕНКА ЭФФЕКТИВНОСТИ ПРЕПАРАТОВ ХОНДРОИТИН СУЛЬФАТА И ГИАЛУРОНОВОЙ КИСЛОТЫ ПРИ ОСТЕОАРТРОЗЕ КОЛЕННЫХ СУСТАВОВ В исследовании проведена сравнительная оценка эффективности лечения больных остеоартрозом коленных суставов (ОА КС) препаратами хондроитин сульфата (ХС) и внутрисуставного введения гиалуроновой кислоты (ГК), а также их влияние на потребность в НПВП-терапии и качество жизни больных. В 12месячное исследование включено 45 пациентов обоего пола с ОА КС в возрасте от 35 до 82 лет со средней давностью болезни 7 лет.
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