The comparative analysis of different methods of autological stromal cells admission functional results in the treatment of patients with refractory angina

Abstract

The aim of the study was to optimize the technique of cellular cardiomyoplasty in patients with refractory angina. The results of treatment of 75 patients with refractory angina who were hospitalized in the Emergency and Reconstructive Cardiac Surgery Department of the "V. Gusak Institute of Emergency and Reconstructive Surgery of NAMS of Ukraine" from 2007 to 2013 were analyzed. The intramyocardial implantation of autologous mesenchymal bone marrow stem cells in patients with chronic coronary heart disease and severe left ventricular failure is a safe method that can improve clinical data and prognosis. This method can be used as the first line of coronary heart disease treatment to prepare a patient for aortocoronary bypass. The injection of bone marrow stem cells in ischemic segments improves perfusion without induction of additional myocardial scarring. Unfortunately, currently there is no alternative to adequate therapy of patients with cardiac insufficiency, which is possessed of a minimal number of negative effects on one hand and could give patients a real chance for a positive effect of therapy on other one. Keywords: stem cells, cardiomyoplasty, heart failure, refractory angina.