Abstract
Fluoxymesterone (FM), a synthetic nonaromatizable androgen, and testosterone (T) were injected into castrated male rabbits in doses of 4 and 12 mg per animal and day for 21 days. Both 12 mg of FM and 12 mg of T stimulated sexual behavior, the two hormones being almost equally effective. The lower dose, 4 mg, had only slight effects on sexual behavior. FM was found to be more active than T in stimulating growth of the seminal vesicle. Since FM cannot be aromatized to estrogens, it is suggested that aromatization is not important for androgenic activation of sexual behavior in male rabbits. This hypothesis is discussed in relation to previous studies in which dihydrotestosterone was found to be much inferior to T in stimulating rabbit sexual behavior.
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