Abstract
Wound healing and tissue regeneration are a field of clinical medicine presenting high research interest, since various local and systematic factors can inhibit these processes and lead to an inferior result. New methods of healing enhancement constantly arise, which, however, require experimental validation before their establishment in everyday practice. Platelet-rich plasma (PRP) is a well-known autologous factor that promotes tissue healing in various surgical defects. PRP derives from the centrifugation of peripheral blood and has a high concentration of growth factors that promote healing. Recently, the use of adipose-derived mesenchymal stem cells (ADMSCs) has been thoroughly investigated as a form of wound healing enhancement. ADMSCs are autologous stem cells deriving from fat tissue, with a capability of differentiation in specific cells, depending on the micro-environment that they are exposed to. The aim of the present comprehensive review is to record the experimental studies that have been published and investigate the synergistic use of PRP and ADMSC in animal models. The technical aspects of experimentations, as well as the major results of each study, are discussed. In addition, the limited clinical studies including humans are also reported. Future perspectives are discussed, along with the limitations of current studies on the long-term follow up needed on efficacy and safety.
Highlights
This review aims to present the basic characteristics of platelet-rich plasma, adiposederived mesenchymal stem cells and their synergistic effects on experimental models published in the literature
Toward this orientation, Ding et al examined if the combination of adipose-derived mesenchymal stem cells (ADMSCs) sheets and autologous platelet-rich fibrin (PRF) application is superior to their individual use in peri-implant mandibular bone defects of a canine experimental model
Based on the gratifying results of bone mesenchymal stem cells and autologous Platelet-rich plasma (PRP) on bone regeneration published by Ueda et al [54] and the extending role of ADSCs, Nakano et al [55] aimed to clarify the role of dedifferentiated adipocytes (DFATs), which are adipocyte-derived fibroblast-like cells with great proliferation and differentiation capacity, alone or in combination with activated PRP in regenerating iatrogenic bone defects in rat calvaria
Summary
Dimitris Tatsis 1,2, * , Varvara Vasalou 1 , Efstathios Kotidis 1 , Elissavet Anestiadou 1 , Ioannis Grivas 3 , Angeliki Cheva 4 , Georgios Koliakos 5 , Gregory Venetis 2 , Manousos-George Pramateftakis 1 , Nikolaos Ouzounidis 1 and Stamatis Angelopoulos 1. Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affil-
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