Abstract
AbstractBackgroundAmyloid‐beta (Aβ) and vascular risk factors are commonly observed together among cognitively unimpaired adults. Here, we examined the interactive associations of Aβ burden and systemic vascular risk with respect to longitudinal patterns of neurodegeneration. Secondarily, we assessed whether systemic vascular risk associations with brain atrophy were modified after adjusting for imaging based markers of white matter integrity (white matter hyperintensities (WMH) and diffusion‐derived fractional anisotropy).MethodsParticipants were 197 adults (age=73.5±6.1 years) from the Harvard Aging Brain Study with at least two MRI scans over a median of 4.5 years. Baseline Aβ burden was measured with Pittsburgh Compound‐B PET. Vascular risk was quantified with the Framingham Heart Study general cardiovascular disease risk score. Altered white matter microstructure was measured via diffusion‐derived fractional anisotropy and WMH burden was quantified using FLAIR images. Brain atrophy was assessed longitudinally with serial structural MRI. Aβ burden and vascular risk were examined as interactive and independent predictors of brain atrophy in separate linear mixed models, adjusting for age, sex, education, APOE ε4 status, and intracranial volume (where appropriate).ResultWe found a significant interaction between elevated Aβ burden and higher vascular risk in relation to faster atrophy within frontal (t=‐2.95, p=0.003) and anterior temporal lobes (t =‐2.32, p=0.021), thalamus (t=‐2.61, p=0.010) and striatum (t =‐2.17, p=0.031). Higher Aβ burden, but not vascular risk, was associated with faster atrophy in the parietal lobes (Aβ: t=‐4.14, p<0.001; vascular risk: t=‐1.54, p=0.124), occipital lobes (Aβ: t=‐2.95, p=0.003; vascular risk: t=‐0.63, p=0.526), and hippocampus (Aβ: t=‐2.72, p=0.007; vascular risk: t=0.207, p=0.836). These effects remained very similar after adjusting for WMH and fractional anisotropy measures.ConclusionElevated vascular risk was associated with accelerated Aβ‐related atrophy in frontal and anterior temporal regions. However, higher Aβ burden alone was correlated with greater atrophy in regions often associated with a canonical AD pattern of neurodegeneration, including the hippocampus and parietal regions. These findings highlight interactions between vascular and Aβ‐related pathways with respect to brain atrophy, and the potential benefit of managing vascular risk factors as a possible intervention to slow regional neurodegeneration in preclinical Alzheimer’s disease.
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