Abstract
The aim of the study was to assess the combined effects of chromium(III) supplementation and iron deficiency on the copper (Cu) and zinc (Zn) status in female rats. The Cr, Fe, Cu and Zn dietary and tissular levels were measured by Atomic Absorption Spectrometry (AAS) method. The data show that chromium(III) supplementation compensated for the negative effects of Fe deficiency on the Cu content but it deepened the effect on Zn levels in the female rats. Detailed data on the status of trace elements and their interactions in healthy subjects and patients with metabolic disorders (e.g. anaemia, diabetes mellitus) are strongly required for effective nutritional and therapeutic strategies.
Highlights
Both iron (Fe) deficiency and its excess are manifested by health-related symptoms
The deficiency or accumulation of some trace elements may stimulate another pathway of their metabolism, which might induce diseases
Fe accumulation in the liver may lead to insulin resistance by interfering with the insulin capacity to inhibit hepatic glucose production [5,6,7,8,9]
Summary
Both iron (Fe) deficiency and its excess are manifested by health-related symptoms. Deficiency or the accumulation of macro- and microelements in the organism is caused by environmental pollution, improper diet or metabolic disorders [1]. The deficiency or accumulation of some trace elements may stimulate another pathway of their metabolism, which might induce diseases. The interaction between these elements may stimulate many nutritional disorders [2]. Common nutritional deficiencies often include iron deficiency, which is generally related with low Fe intake, diseases, poor absorption, excessive blood loss, and increased physiological requirements as in pregnancy [3]. Iron deficiency is a common cause of anaemia. Fe accumulation in the liver may lead to insulin resistance by interfering with the insulin capacity to inhibit hepatic glucose production [5,6,7,8,9]
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