Abstract
Objectives This study investigated the cytoprotective effects of N-acetylcysteine (NAC) and iloprost on spinal cord ischemia in an experimental model. Materials and methods Thirty-five (male) New Zealand white rabbits were included in five study groups ( n=7, each group). One group served as Sham. Rabbits in other groups had their abdominal aorta cross-clamped just above the iliac bifurcation for 40 min. During aortic cross clamping, iloprost, NAC, both iloprost and NAC or saline (control) were infused. Results In NAC, iloprost, and iloprost+NAC groups, neurological status of rabbits (Tarlov score) 24 and 48 h after the operation was better than the control group ( p<0.01), but worse than the Sham group ( p<0.01). There was minimal neuronal damage in the iloprost treated groups compared to the NAC group ( p<0.05). Mean viability index values in NAC, iloprost and iloprost+NAC groups were higher than the control group ( p<0.01). Viability index in the NAC group was lower than the iloprost and iloprost+NAC groups. Conclusions The use of iloprost and NAC may provide better protection from spinal cord ischemia.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: European Journal of Vascular and Endovascular Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
