Abstract
Isogeneic adenocarcinomas of female C3H mice were treated with bleomycin and local hyperthermia and tumour regrowth delay was measured. Hyperthermia had a synergistic effect on the drug induced growth delay. Heating to 44.5 °C for 20 min, 30 min after bleomycin, increased the slope of the dose response curve by a factor of 2.7 whereas the same heat treatment given 30 min before the drug increased the slope of the dose response curve only by a factor of 1.5 .
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