Abstract
Water-insoluble fibrous complexes of deoxyribonucleic acid (DNA) and protamine of widely varying composition were obtained by mixing aqueous neutral solutions of the two materials. Depending on the relative proportions of DNA and protamine the complexes stained preferentially with acid or basic dyes. If the DNA and protamine were mixed in very dilute aqueous solution no precipitation took place: a powder soluble in water but insoluble in dilute salt solution was left in drying. This material resembles the undissociated nucleoprotein obtained by extracting cells with water, and the protamine is associated with the DNA in aqueous solutions ( i.e. cannot be removed by dialysis) but is dissociated in concentrated salt solutions. Structures are proposed for the water-soluble and insoluble complexes which account for their physical properties.
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