Abstract
IntroductionThe combination of platelet count and neutrophil to lymphocyte ratio (COP-NLR) has been shown to provide prognostic information in several cancers, whereas its prognostic value in renal cell carcinoma (RCC) has not been reported. The objective of the present study was to examine the preoperative prognostic value of the COP-NLR in patients with localized RCC undergoing nephrectomy.Material and MethodsThe record of 268 patients, who underwent nephrectomy due to a diagnosis of RCC at our institute was analyzed in the study. The cut-off value of platelet count and NLR were defined by receive operating characteristic (ROC) analysis and the areas under the curve (AUC). Patients with both an increased platelet count (> 310×109/l) and an elevated NLR (> 3.85) were assigned to the score 2, and patients with one or neither of these indicators were assigned to the score 1 or 0, respectively. The impact of the COP-NLR and other clinicopathological characteristics on overall survival (OS) and recurrence-free survival (RFS) were evaluated using the univariate and multivariate Cox regression analysis.ResultThe median follow-up duration after surgical resection was 60 months. Multivariate analysis using the 10 clinicopathological findings selected by univariate analyses demonstrated that the preoperative COP-NLR was an independent prognostic factor for OS (HR: 2.32, 95%CI: 1.22 to 4.26, p=0.011) and RFS (HR: 1.91, 95%CI: 1.02 to 3.53, p=0.044).ConclusionThe findings of the current study suggested that the preoperative COP-NLR is an independent prognostic indicator of OS and RFS for patients with localized RCC.
Highlights
The combination of platelet count and neutrophil to lymphocyte ratio (COP-neutrophil lymphocyte ratio (NLR)) has been shown to provide prognostic information in several cancers, whereas its prognostic value in renal cell carcinoma (RCC) has not been reported
The findings of the current study suggested that the preoperative COP-NLR is an independent prognostic indicator of overall survival (OS) and recurrence-free survival (RFS) for patients with localized RCC
We examined the predictive value of preoperative measurement of COP-NLR for localized RCC patients who underwent curative nephrectomy
Summary
The combination of platelet count and neutrophil to lymphocyte ratio (COP-NLR) has been shown to provide prognostic information in several cancers, whereas its prognostic value in renal cell carcinoma (RCC) has not been reported. The objective of the present study was to examine the preoperative prognostic value of the COP-NLR in patients with localized RCC undergoing nephrectomy. In the last few years, the other inflammation-based prognostic scores, including the neutrophil lymphocyte ratio (NLR), derived neutrophil-tolymphocyte ratio (dNLR), and platelet lymphocyte ratio (PLR) have been reported to render prognostic value in many cancers, including RCC [7,8,9,10,11]. We examined the predictive value of preoperative measurement of COP-NLR for localized RCC patients who underwent curative nephrectomy
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