THE COMBINATION OF EXERCISE AND ASCORBIC ACID DECREASE BLOOD GLUCOSE LEVEL AND TEND TO AMELIORATE PANCREATIC ISLETS AREA ON HIGH CARBOHYDRATE DIET RATS

Lilik Herawati,Lina Lukitasari,Bambang Purwanto,Gadis Meinar Sari,Rimbun Rimbun

doi:10.22159/ijap.2019.v11s3.m1019

Lilik Herawati, Lina Lukitasari + Show 3 more

Open Access

https://doi.org/10.22159/ijap.2019.v11s3.m1019

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Abstract

Objective: This study is conducted to determine the protective effects of physical exercise and ascorbic acid on increasing blood glucose (BG) levels and islet pancreatic area in high-carbohydrate (HC) diet rats. Methods: A total of 20 rats were divided into four groups: Control group which was a HC and treatment groups which were HC plus exercise (HCEx), HC plus ascorbic acid (HCAs), and HCEx and ascorbic acid (HCExAs). The duration of treatment was 9 weeks. Swimming to exercise held 6 times a week and ascorbic acid dose was 9 mg. Results: It showed that the smallest body weight was HCEx group. BG difference (before and after treatment = BG diff) had a significant difference (p=0.021) among groups, and the lowest level of BG diff was HCEx group. HCAs had the biggest BG diff. However, there was no significantly difference among groups on islet pancreatic area, but HC group had the largest area. Conclusion: This study suggests that a combination of exercise and ascorbic acid on HC diet subject may regulate BG level compared to the exercise or ascorbic acid alone. However, they do not influence pancreatic islet area.

Highlights

Prolong increasing calories can induce obesity and metabolic disease such as diabetes
The group that consisted of a HC diet group as control group was given standard diet plus sugar solution, HC plus exercise (HCEx) group was given treatment as HCEx, HC plus ascorbic acid (HCA) group was given treatment as HCA solution, and HCEx and ascorbic acid group (HCExAS) were given treatment as HCEx and ascorbic acid
This research revealed that there was no difference on Body weight (BW) including after treatment and the change of BW

Summary

Introduction

Prolong increasing calories can induce obesity and metabolic disease such as diabetes. It was known that there was an association in increasing 150 kcal/person/day in sugar with rising diabetes prevalence by 1.1% [1]. The prediction of diabetes prevalence in 2035 is 592 millions [2]. Establish prevention to diminish calories excess is physical exercise. Exercise can stimulate independent insulin-glucose uptake by cells and may provide a protective effect for beta cells. It reveals that exercise can stimulate free radical production. There is no balance with internal antioxidant, and it can lead to pathologic process. Imbalance of free radicals and antioxidant is one of the several factors which may trigger the destruction of beta-cells of pancreatic islets [4]

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