The combination of a bifocal germinoma and arteriovenous malformations of the brain in children. Clinical observation and review of the literature

Abstract

Primary intracranial germ cell tumors are rare heterogeneous group of neoplasms presented several histological types with different biological profile and response to therapy. Pure germinomas make up no more than 5 % of malignant tumors of the central nervous system in children, bifocal germinomas account for only 5–10 % of all germinomas. Radiotherapy and chemotherapy are usually used in intracranial germ cell tumors. The choice of initial therapy options is dependent on the histological variants of tumors, and the prevalence of the process (M-stage). Vascular malformations of the brain is rare in childhood, in a large proportion of cases, which is a random finding and can significantly affect the treatment policy in the presence of a brain disease (eg, neoplasia). We present a rare case of a combination of clinical bifocal germinomas and arteriovenous malformations of the brain in a boy 13 years old