The columnar and layer-specific response properties of neurons in the primary auditory cortex of Mongolian gerbils

Abstract

The columnar and layer-specific response properties of neurons in the primary auditory cortex (AI) of Mongolian gerbils were studied using single-unit recordings of responses to tone-burst stimuli presented to the ear contralateral to the recording side. During near-radial microelectrode penetrations of the AI in 100-μm steps, the best frequency (BF), best threshold (BT), best amplitude (BA), latency, tuning curve and Q 10dB were recorded. Neurons encountered during single penetrations showed similar BFs, indicating a columnar frequency organization, but their latencies and Q 10dBs differed. The BAs and BTs recorded within single penetrations often showed a similar value in the middle cortical layers. The latencies and Q 10dBS of these neurons exhibited a tendency toward a layer-specific distribution. The latencies of neurons located in layers I–V were longer than those located in layer VI. The Q 10dBs of neurons located in layers III and IV were higher than those located in layers I and VI. These results are almost consistent with those of previous studies on frequency representation, and indicated the existence of an integrative mechanism of frequency processing in the AI. This is the first study in which a layer-specific, partially columnar organization for stimulus amplitude is described.