Abstract
The quantitative reaction between sodium l,2-naphthoquinone-4-sulfonate and primary amines has been applied to the assay of certain local anesthetic compounds. The improved colorimetric method which is employed is particularly useful since it is simple and highly selective, and yet provides a relatively high degree of precision and accuracy. While the presence of secondary amines causes interference with most other chemical methods of assay, neither secondary nor tertiary amines display any adverse effect in the procedure described. Specific application to a commercial dosage form is discussed.
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