Abstract

<sec><strong>Background:</strong> Depression is accompanied by cognitive control defects. Transcranial direct current stimulation (tDCS) has been found to be a promising non-invasive treatment for depression. Studies have explored whether tDCS can improve cognitive function in patients with depression, but the results were not consistent. </sec><sec><strong>Methods:</strong> The study summarized the relevant evidence from sham-controlled randomized controlled trials (RCTs) whether prefrontal tDCS improves cognitive function in patients with depression. </sec><sec><strong>Results:</strong> Seventeen sham-controlled studies were selected from 252 papers. Systematic analysis shows that the prefrontal tDCS has a promising prospect in the working memory and emotion process of depression patients; however, there is insufficient evidence to support the reliable influence of tDCS on psychomotor speed, learning, speech process, and overall cognitive function. </sec><sec><strong>Conclusions:</strong> Our review shows that the prefrontal tDCS has positive effects on working memory and emotion processes, but has limited impact on other cognitive functions. </sec>

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