Abstract
Poor learning abilities and impaired memory are increasing their importance in accompany with the increased elderly population and stress exposure. Therefore, the development of cognitive enhancement is required. Recent findings showed that oxidative stress played the important role on the development of cognitive impairment in various conditions. Therefore the development of cognitive enhancer from vegetable possessing antioxidant is focused. The present study is carried out to determine the effect of dried tomato pomace powder on learning and memory both in normal and cognitive impairment conditions. Adult male Wistar rats, weighing 180-200 g, were orally given dried tomato pomace at various doses ranging from 2, 10 and 50 mg kg-1 BW at a period of 14 days. The animals were determined the cognitive enhancing effect of tomato pomace after single dose, 7 and 14 days after administration. The results showed that tomato pomace significantly decreased escape latency but increased retention time. In addition, we also determined the cognitive enhancing effect of this substance in cognitive deficit condition. In this part, all animals were induced cognitive deficit using scopolamine injection via intraperitoneal route after 14 days of treatment. Again, tomato pomace also improved cognitive impairment. Tomato pomace is the potential cognitive enhancer. However, the precise underlying mechanism is still required further investigation.
Highlights
Poor learning abilities and impaired memory have been recognized as one important problem nowadays
The results showed that vehicle produced no significant change on escape latency
Aricept and dried tomato pomace treated group at dose of 2 mg kg−1 BW significantly decreased escape latency while no significant changes were observed in vitamin C treated group and dried tomato pomace treated group at dose of 10 and 50 mg kg−1
Summary
Poor learning abilities and impaired memory have been recognized as one important problem nowadays. Tomato or Lycopersicon Esculentum, a plant in the family of Solanaceae, is one of the most frequently consumed vegetables in Thailand and worldwide. It is a good source of potassium, folate and the vitamins A, C and E. In addition to its micronutrient benefits, tomato contains valuable phytochemicals, including carotenoids such as lycopene and betacarotene. It contains polyphenols such as flavonoids especially quercetin and kepferol (Canene-Adams et al, 2005). It had been reported that lycopene, one of the active
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