Abstract
Multiple sclerosis (MS) is a chronic disease characterized by multiple areas of central nervous system inflammation, demyelination and axonal loss. Hereditary spastic paraparesis (HSP) is characterized clinically by progressive spasticity and weakness of the lower limbs and pathologically by retrograd axonal degeneration of the corticospinal tracts and posterior columns. We identified a patient with clinical history and investigation findings consistent with the concurrence of both MS and HSP. Laboratory and radiological investigations, cognitive tests were performed. Genetic confirmation for spastin gene mutation has been completed. If this coexistence is not coincidence the mutation in the spastin gene may be a strong susceptibility locus for MS.
Highlights
-c clinically by progressive spasticity and weakness of the lower limbs and pathologically by n retrograd axonal degeneration of the cortio cospinal tracts and posterior columns
Harding N (1993) divided Hereditary spastic paraparesis (HSP) syndromes into pure and bers of the family had a history likely to HSP and three members had a history of Multiple Sclerosis (MS)
Ankle clonus with extensor plantar responses and the diagnosis of MS was cor- The patient’s 21-year-old son was affected were examined
Summary
-c clinically by progressive spasticity and weakness of the lower limbs and pathologically by n retrograd axonal degeneration of the cortio cospinal tracts and posterior columns. Genetic confirmation for spastin gene mutation has been completed. A 34 years old male was referred to our outpatient clinic with one week history of tight, heavy sensation affecting his left arm and leg. He had bilateral gaze evoked nystagmus, mild spastic gait abnormality, left ankle clonus and hipertonicity of both legs with extensor plantar responses.
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