The Coagulation Parameters Among Healthy Menopausal Sudanese Women

Abstract

Background: Menopause is a natural stage in life and part of the aging process. it marks when a woman’s period stops as her ovaries stop producing eggs. Many changes take place in the physiological parameters some of which are known to enhance the risk of vascular-related diseases such as stroke and ischemic heart disease. This study aimed to estimate the platelets count, PT, APTT, fibrinogen level D-dimer, and protein C level among Healthy Menopausal Sudanese Women. Material and methods: This was a case-control study conducted at the laboratory of the national university at Khartoum state during the period of December 2022 to April 2023. Apparently, healthy menopausal women who lost their menstrual period for more than one year were included as a case group, and apparently healthy women during the reproductive period were included as a control group. The platelets were counted by using Automated Hematology Analyzer, Sysmex KX 21N (series SN B 2010), PT, APTT by coagulometer (Automated Bio Bas), Fibrinogen level by using the coagulometer (Automated Bio Bas) by BioMed-Fibrinogen kite BioMed-Fibrinogen kite, I chroma was used for the D-dimer, protein C was measured by using (URIT 660 AESKULISA Protein C and S Microplate read. Results: In the case group the means of platelets count, PT, APTT, Fibrinogen, D-dimer, and Protein C were; (251.3±38.2), (16.9±2.1), (32.9±7.7), (381.0±269.1) (0.59±0.17) and (89.9±16.3) respectively. while in the control group, the means of platelets count, PT, INR, APTT, Fibrinogen, D-dimer, and Protein C were; (291.8±73.5), (13.5±1.5), (31.3±2.7), (212.5±77.3) (0.33±0.12) and (82.2±14.2) also respectively. when comparing the parameters means between the case and control group the results revealed; there was a significant decrease in platelets counts (p. v = 0.001), a significant increase in PT and fibrinogen levels (p. v = 0.000), and insignificant differences for the APTT, D-dimer, and protein C (p. v > 0.05). In addition to that, there was a negative correlation between the parameters and the age and the A menorrhea (p. v > 0.05) Conclusion: In the Sudanese menopausal women, there was a significant decrease in platelets counts, and a significant increase in PT and fibrinogen levels, with insignificant differences for the APTT, D-dimer, and protein C when compared between the case and control group, in addition, the parameters had a negative correlation with the age and the A menorrhea.