Abstract
Low-temperature (cryo) electron microscopy has been established as a promising approach for alleviating technical problems encountered in electron microscopy of life science materials. Cryofixation freezes in the native situation of biological material, with the rapid freezing process preventing redistribution of water-soluble elements in cellular and non-cellular compartments. Thus it becomes possible to correlate tissue morphology with chemical and physical properties.The use of cryo techniques puts stringent demands on the electron microscope technology: an ultra-high vacuum, including special measures to tackle the water vapour released by the specimen; stable, low-drift cryo-temperature specimen holders; special functions providing low-dose imaging conditions; electron dose indicators; and a TV system for observation under low-level illumination. The new CM-CRYO combines these features with the ease of use of the CM microscope concept and the quality of the TWIN objective lens system.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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