Abstract
Backgroundc-MET is an oncogene protein that plays important role in gastric carcinogenesis and has been introduced as a prognostic marker and potential therapeutic target. The aim of this study was to evaluate the frequency of c-MET overexpression and its relationship with clinicopathological variables in gastric cancer of Iranian population using tissue microarray.MethodsIn a cross sectional study, representative paraffin blocks of 130 patients with gastric carcinoma treated by curative gastrectomy during a 2 years period of 2008–2009 in two university hospitals in Tehran-Iran were collected in tissue microarray and c-MET expression was studied by immunohistochemical staining.ResultsFinally 124 cases were evaluated, constituted of 99 male and 25 female with the average age of 61.5 years. In 71% (88/124) of tumors, c-MET high expression was found. c-MET high expression was more associated with intestinal than diffuse tumor type (P = 0.04), deeper tumor invasion, pT3 and pT4 versus pT1 and pT2 (P = 0.014), neural invasion (P = 0.002) and advanced TNM staging, stage 3 and 4 versus stage 1 and2 (P = 0.044). The c-MET high expression was not associated with age, sex, tumor location, differentiation grade and distant metastasis, but relative associations with lymph node metastasis (P = 0.065) and vascular invasion (P = 0.078) were observed.Conclusionsc-MET oncogene protein was frequently overexpressed in Iranian gastric carcinomas and it was related to clinicopathological characteristics such as tumor type, depth of invasion, neural invasion and TNM staging. It can also support the idea that c-MET is a potential marker for target therapy in Iranian gastric cancer.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9744598757151429
Highlights
Gastric carcinoma is currently the second leading cause of cancer death in the world
The pathological features of tumors including location, size, grade of differentiation, tumor classification according to Lauren classification [30], TNM staging according to American Joint Committee on Cancer/International Union against Cancer (UICC) [31], neural and vascular invasions and type of surgery were recorded
C-MET staining report c-MET expression was localized in both cytoplasm and membrane of tumoral cells (Figures 1, 2 and 3)
Summary
Gastric carcinoma is currently the second leading cause of cancer death in the world. Its incidence and mortality declined through the past decades; it remains the fourth most common cancer in the world. It is estimated that close to one million new cases are occur each year in the world and more than 700.000 deaths are directly related to this problem[1,2]. In Iran, gastric cancer is the second most common and accounts for 10% of all cancers and is the first cause of cancer related mortality in both sexes [3,4]. More than 7300 new cases are occurred annually which mostly presented in stage III and IV and half of them died before the first year of diagnosis. The overall 5-year survival rate of gastric cancer in Iran was 12.8% which is dramatically lower than Japan and developed western countries [4,5]
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