The clinico-functional heterogeneity of changes in the coronary and cerebral blood circulation with the arterial hypertonia of the I stage

Abstract

Purpose of this investigation: to determine the early signs of the typological disturbances of coronary and cerebral blood circulation with the arterial hypertonia of the I stage. Materials and the methods. Is carried out a study of cardio-cerebrovascular system in 147 men in the age of 30-59 years with the arterial hypertonia of the I stage, control group they composed 37 clinically healthy men at the age from 29 to 42 years. Results and their consideration. Substantial changes in the coronary and cerebral blood flow with the I stage of arterial hypertonia to the development of the clinical manifestations of the defeat of the vessels of heart and brain are revealed. Is carried out daily monitoring arterial pressure and electrocardiogram, rhythmocardiography, bicycle ergometry, echocardiography, transcranial dopplerography, ultrasonic diagnostics of the main arteries of head and neck. Statistical processing of the results of a study is carried out by the standard methods within the framework of software Statistica for Windows, version 6 and recommended in the management on the biomedical statistics. Obtained by us data give grounds for expanding the criteria, which characterize the defeat of the target organs at the early stage arterial hypertonia. To these criteria we carried the clinical signs of the initial manifestations of the insufficiency of the blood supply of brain and discirculatory encephalopathy of the I stage, and also painless ischemia of the myocardium in the absence of stenocardia and its equivalents, presence of the minimum signs of the disturbance extra and intracranial blood flow (high-speed indices and the asymmetry of blood flow, the index of cerebrovascular reactivity and the presence of microembolic signals). Conclusions. The clinico-functional heterogeneity of changes in the coronary and cerebral blood circulation with the arterial hypertonia of the I stage requires the revision of the standards of the inspection of patients with the development of the increased numbers of arterial pressure, and also start of the new criteria of the early defeat of heart and brain in clinical recommendations.