The clinical value of urinary microalbumin detection in patients with primary hypertension

Abstract

Objective To investigate the clinical value of urinary microalbumin detection for the diagnosis of early renal injury in patients with primary hypertension. Methods Urinary levels of α1-micraglobulin (Uα1-MG), β2-microglobulin (Uβ2-MG), albumin (UALB), and immune globulin (UIGG) were measured by competition immunoassay in 86 patients and 40 healthy subjects. Results As compared with the healthy subjects, UIGG level increased significantly (P<0.05) and levels of Uαl-MG, Uβ2-MG, and UALB elevated markedly in patients with primary hypertension (P<0.01). As compared with patients with grade 1 hypertension, levels and detection rates of Uαl-MG, Uβ2-MG, and UALB increased obviously in patients with grades 2-3 hypertension (P<0.01 and P<0.05). Conclusions Urinary microalbumin is helpful in diagnosing early renal injury in primary hypertension, reflecting the site and degree of renal injury. α1-micraglobulin, β2-microglobulin. and albumin are the most sensitive indicators. Regular detection of urinary microalbumin has important clinical values. Key words: Primary hypertension; Renal injury; Urinary microalbumin