Abstract
Background To explore the clinical value of enhanced computed tomography (enhanced CT), magnetic resonance imaging (MRI), carcinoembryonic antigen (CEA), and cancer antigen 199 (CA199) in the diagnosis of rectal cancer (RC). Methods A total of 156 patients with RC confirmed by postoperative pathology admitted to the Affiliated Yantai Yuhuangding Hospital of Qingdao University from March 2018 to November 2020 were included in the malignant group, and 52 patients with chronic proctitis in the benign control group. All patients underwent preoperative enhanced CT, MRI scans, and serum CEA and CA199 tests. The accuracy, sensitivity, and specificity of single and combined enhanced CT, MRI, CEA, and CA199 tests for the clinical staging of RC were calculated. Results The postoperative pathological diagnosis showed that 35 cases of 156 RC patients were at T1 stage, 29 cases were at T2 stage, 24 cases were at T3 stage, 11 cases were at T4 stage, 23 cases were at N0 stage, 21 cases were at N1 stage, 8 cases were at N2 stage, 3 cases were at M0 stage, and 2 cases were at M1 stage. The positive rate of MRI in the diagnosis of RC was higher than that of enhanced CT. Serum CEA and CA199 levels in the malignant group were significantly increased compared with the benign group. The sensitivity, specificity, and accuracy of the combined detection were significantly higher than those of the single detection. Conclusion Compared with enhanced CT, MRI has a higher detection rate of T and N stage in patients with RC. Combined enhanced CT, MRI, CEA, and CA199 can provide more accurate diagnosis and preoperative staging of RC patients.
Highlights
Rectal cancer (RC) is one of the common clinical malignant tumors, which occurs in the mucosa or submucosa. e surface of the rectal cancer (RC) tumor is uneven, the texture is generally hard, and the growth rate is fast
Clinical results show that the treatment and prognosis of patients with RC are closely related to the preoperative staging, and the more accurate the preoperative staging judgment is, the more reasonable the treatment plan can be selected by physicians [6]. erefore, accurate preoperative staging of RC is the key to the prognosis of patients and the formulation of the best treatment plan
A total of 156 patients with RC confirmed by postoperative pathology admitted to the Affiliated Yantai Yuhuangding Hospital of Qingdao University from March 2018 to December 2020 were included in this study. ere were 95 males and 61 females. e average age was 52.5 ± 11.5 years from 27 to 69 years. ere were 9 cases of highly differentiated adenocarcinoma, 124 cases of moderately differentiated adenocarcinoma, and 23 cases of poorly differentiated adenocarcinoma. ere were 89 cases of middle and upper RC, and 67 cases of lower RC. e tumor diameter ranged from 1.5 to 7.7 cm, with an average of 4.9 cm. 52 patients with chronic proctitis were selected as the benign control group
Summary
Rectal cancer (RC) is one of the common clinical malignant tumors, which occurs in the mucosa or submucosa. e surface of the RC tumor is uneven, the texture is generally hard, and the growth rate is fast. Clinical results show that the treatment and prognosis of patients with RC are closely related to the preoperative staging, and the more accurate the preoperative staging judgment is, the more reasonable the treatment plan can be selected by physicians [6]. To explore the clinical value of enhanced computed tomography (enhanced CT), magnetic resonance imaging (MRI), carcinoembryonic antigen (CEA), and cancer antigen 199 (CA199) in the diagnosis of rectal cancer (RC). All patients underwent preoperative enhanced CT, MRI scans, and serum CEA and CA199 tests. E accuracy, sensitivity, and specificity of single and combined enhanced CT, MRI, CEA, and CA199 tests for the clinical staging of RC were calculated. Compared with enhanced CT, MRI has a higher detection rate of T and N stage in patients with RC. Combined enhanced CT, MRI, CEA, and CA199 can provide more accurate diagnosis and preoperative staging of RC patients
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