The clinical value of measuring RNFL in diagnosis of primary open-angle glaucoma with high myopia

Abstract

Objective To evaluate the clinical value of measuring retinal nerve fiber layer (RNFL)thickness using optical coherence tomography (OCT) in diagnosis of primary open-angle glaucoma (POAG)with high myopia. Methods We collected 73 eyes of 40 cases diagnosed with high myopia (diopter ≥-6.00D). They were divided into simple high myopia (group A) and high myopia with POAG (group B). All patients underwent intra-ocular tension, goniscope examination, visual field and OCT. Results In group A, average intraocular pressure (lOP): 16.57±2.43 (mmHg); visual field examination: mean sensitivity: 23.63±3.70; the mean RNFL thickness around optical nerve head were in the superior: 1 17.64± 15.78 (μm), inferior:126.05± 22.55 (μ m), nasal: 95.69± 34.99 (μ m), temporal: 100.1± 27.25 (μ m), respectively. In group B, average lOP: 26.45± 6.02 (mmHg); visual field examination: mean sensitivity: 15.41 ± 7.63; the mean RNFL thickness around o7tical nerve head were in the superior: 99.38 ± 36.39 (μ m), inferior: 95.10±33.85 (μm),nasal: 68.00±17.56 (μ m), temporal: 70.62± 25.57 (μm), respectively. Independent-Samples T Test was applied for RNFL thickness comparisons of different quadrants between two groups. The results showed there was significant difference between two groups (P ＜0.01). Conclusions It has significant clinical meaning to exactly evaluate the application value of measuring retinal nerve fiber layer in POAG with high myopia. Key words: High myopia; Primary open-angle glaucoma; Retinal nerve fiber layer