The clinical value of early postoperative enteral nutrition in patients with cholangiocarcinoma

Abstract

Objective To compare the clinical value of early enteral nutrition and parenteral nutrition therapy in postoperative patients of cholangiocarcinoma. Methods 56 cases of cholangiocarcinoma patients were randomly divided into early enteral nutrition group (EPN group) and parenteral nutrition group (PN group). All patients received nutritional support on the basis of metabolic support. Leukocyte count and neutrophil percentage decrease rate, total bilirubin decrease rate and hepatase (valley-C conversion) were counted at 3 and 7 days after operation.The decrease rate of aminase and glutamic oxaloacetic transaminase, recovery time of intestinal function (anal exhaust and defecation), incidence rate of surgical site infection (abdominal cavity and wound), hospitalization time after operation, incidence rate of bile leakage and hospitalization cost were compared between the two groups. Results The recovery time of intestinal function [(51.2±4.4)h], the decrease rate of leukocyte count (0.438 7±0.191 5) and neutrophil ratio (0.179 5±0.046 1), the decrease rate of bilirubin (0.502 5±0.153 5), alanine aminotransferase (ALT) (0.688 1±0.113 3), aspartate aminotransferase (AST) (0.617 0 ± 0.178 8) and hospitalization expenses [(87 852.37±9 127.04)yuan] in EPN group were better than those in PN group [(72.0±12.9)h, 0.090 5±0.120 3, 0.083 4±0.036 8, 0.201 5±0.077 8, 0.251 6±0.419 0, 0.230 9±0.437, (109 036.69±7 949.71)yuan, P 0.05). Conclusions Early enteral nutrition has obvious advantages in postoperative recovery of patients with cholangiocarcinoma. Key words: Bile duct neoplasms/SU; Enteral nutrition; Parenteral nutrition