Abstract
Aim: To perform a meta-analysis of prospective, two-arm studies examining the clinical utility of using the combinatorial pharmacogenomic test, GeneSight Psychotropic, to inform treatment decisions for patients with major depressive disorder (MDD). Patients & methods: The pooled mean effect of symptom improvement and pooled relative risk ratio (RR) of response and remission were calculated using a random effect model. Results: Overall, 1556 patients were included from four studies, with outcomes evaluated at week 8 or week 10. Patient outcomes were significantly improved for patients with MDD whose care was guided by the combinatorial pharmacogenomic test results compared with unguided care (symptom improvement Δ=10.08%, 95% CI: 1.67-18.50; p=0.019; response RR=1.40, 95% CI: 1.17-1.67; p<0.001; remission RR=1.49, 95% CI: 1.17-1.89; p=0.001). Conclusion: GeneSight Psychotropic guided care improves outcomes among patients with MDD.
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