The clinical study of ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute combined with HIFU in the treatment of uterine fibroids

Abstract

Abstract Objective The aim of this study was to investigate the energy deposition in the target area of high intensity focused ultrasound (HIFU) with ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute Methods Eighty patients with hysteromyomas were randomly divided into two groups: group HIFU (group H) and group HIFU combined with ultrasound-guided intra-hysteromyoma injectionn of ethyl alcohol absolute (group E + H). Patients in group E + H received an ultrasound-guided injection of absolute ethyl alcohol 1 h before HIFU treatment. The irradiation time, irradiation dose, energy efficiency factor (radiation energy required for ablation of a myoma per unit of volume), grey variation, pain score, and adverse reactions were compared between the two groups. An independent sample t-test was used with a two-tailed P-value of < 0.05. Results The irradiation time, irradiation dose, and energy efficiency factor were significantly lower in group E + H than those in group H (P < 0.05). The hysteromyomas of patients in group E+H appeared as dominantly hyperechoic masses, and those of patients in group H appeared as hyperechoic tissue (non-mass). The incidence of adverse reactions and pain score were higher in group H than those in group E + H (P < 0.05). Conclusion Ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute can enhance the energy deposition of HIFU in the uterine fibroids, improve the treatment efficiency, shorten the treatment time, reduce the treatment dose, and reduce the pain and complications for the patients.