The clinical study of continuous renal replacement therapy in the treatment of severe sepsis complicated with acute kidney injury

Abstract

Objectives To observe the clinical effect of continuous renal replacement therapy(CRRT) in the treatment of severe sepsis complicated with acute kidney injury, so as to provide reference for clinical treatment. Methods We selected 76 cases of severe sepsis complicated with acute kidney injury patients from our Hospital from July 2013 to April 2015, then randomly divided into two groups, CRRT treatment group and conventional treatment group respectively, 38 cases in each group. to compare the vital signs (Body temperature, heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure), Biochemical parameters (PH, hemoglobin, serum creatinine, urea nitrogen, white blood cell count, platelet count, albumin and C reactive protein) before and after treatment between the two groups, and to compare the APACHE II score and survival rate between the two groups before and after treatment. Results After treatment, the body temperature and heart rate in the CRRT group were lower than the conventional treatment group, the body temperature, heart rate in the two groups before and after treatment had statistically significant differences, the systolic blood pressure in continuous renal replacement therapy group after treatment was higher than before treatment, it had statistical significance(P<0.05); after treatment, the differences in PH, SCr, bun, WBC and PLT in patients between the two groups had statistical significance(P<0.05), PH, SCr, bun, WBC, PLT, ALB and hsCRP in CRRT treatment group before and after treatment had statisticallyl sig–nificant differences(P<0.05); after treatment, the APACHE of CRRT group was lower than the conventional treatment group, and the survival rate of CRRT treated group was higher than the conventional treatment group, the difference was statistically significant(P<0.05). Conclusions CRRT can remove metabolic waste, and can maintain the interior environment, and improve short term survival rate for severe sepsis complicated with acute kidney injury patients, therefore it can be recommended in clinical application. Key words: Kidney Diseases; Toxemia; Renal Replacement Therapy