The clinical studay on visual function changes in multiple sclerosis with acute optic neuritis

Abstract

Objective To studay the visual functional disorders of multiple sclerosis with optic neuritis and treat them early to remedy visual function effectively. Methods Visual acuity, funduscopy,visual evoked potentials (VEP), visual field defect, CT and/or MRI were assessed in cases of MS with optic neuritis and MS without optic neuritis patients. CSF determinations and oligoclomal bands were assessed in part of them, by x2 and t test. Results (1)Abnomal visual function test results were commonly observed in patients on visual acuity, optic atrophy, papilledema, visual field defect, VEP. Patients with AON had visual acuity less than 0.1 (P＜0.05 ), compaired with MS without AON. VEP showed the abnormalities in 63.6%～72.7% of MS with AON and 21.4%～28.5% of MS without AON with the feature of prolonged potential time (P＜0.05), compaired with MS without AON. (2)CSF oligoclonal bands were comparable, but CSG IgG synthesis rates in patients with AON were less than in MS without AON (P＜0.05).(3)The rates of visual acuity over 0.5 after high dose of corticosteroid in part of patients were about 31.2%～36.3%. Conclusions Optic neuritis was a common feature of MS. The visual disorders in patients with optic neuritis and MS were common and serious. There were abnormal immunological responses in AON as well as in MS so, the early disgnosis and treatment of high dose of corticosteroid for AON is necessary and imperative. Key words: Optic neuritis; Multiple sclerosis; Visual functional